Journal Club

Upcoming Journal Clubs

Wednesday, March 20, 2024
7:00pm Eastern/6:00pm Central/5:00pm Mountain/4:00pm Pacific

Presenter: 
Magdalene Payne
University of Toronto

Article:
Evaluating the Long-term Impact of Implementing Standardized Postoperative Opioid Prescribing Recommendations Following Pelvic Organ Prolapse Surgery

Join Zoom 
https://us06web.zoom.us/j/86882241441?pwd=hB4Dq8QjKroFqiM69q3QyoxWeAy70E.1

Previous Journal Clubs

Wednesday, January 17, 2024
7:00pm Eastern/6:00pm Central/5:00pm Mountain/4:00pm Pacific

Presenter:
Chelsea Harris
Dalhousie University

Article:
The Effect of Subsequent Pregnancy and Childbirth on Stress Urinary Incontinence Recurrence Following Mid-Urethral Sling procedure: A Meta-Analysis


Wednesday, November 29, 2023
7:00pm Eastern/6:00pm Central/5:00pm Mountain/4:00pm Pacific

Presenter:
Christina Yang
University of Calgary

Article:
Vaginal Estrogen in Breast Cancer

Wednesday, October 11, 2023*
7:00pm Eastern/6:00pm Central/5:00pm Mountain/4:00pm Pacific

Article:
Overextending: A Qualitative Study of Trainees Learning at the Edge of Evolving Expertise

Presenter:
Jena Hall, MD, MEd, FRCSC
University of Calgary

Wednesday, May 10, 2023
7:00pm Eastern/6:00pm Central/5:00pm Mountain/4:00pm Pacific
*No recording available.

Article:
Permanent Compared with Absorbable Suture

Presenter:
Sarah Wozney, MD, FRCSC
Dalhousie University

Wednesday, April 19, 2023
7:00pm Eastern/6:00pm Central/5:00pm Mountain/4:00pm Pacific

Article:
Universal Urogynecologic Consultation and Screening for Fecal Incontinence in Pregnant Women with a History of OASIS: A Cost-Effectiveness Analysis

Presenter
Lina Roa, MD, MPH, FRCSC
Female Pelvic Medicine Reconstructive Surgery Fellow

 

Patient Perspectives on Pooled Surgical Wait Lists in Urogynecology, Pre-and Post-Pandemic
Wednesday, February 8, 2023
7:00pm Eastern/6:00pm Central/5:00pm Mountain/4:00pm Pacific
Hosted by University of Ottawa


Article:
Patient attitudes toward pooled surgical waitlists in urogynecology

 

Efficacy of vaginal Estradiol and Vaginal Moisturizer for Treatment of Postmenopausal Vulvovaginal Symptoms (VVS) 
Wednesday, November 23, 2022
7:00pm Eastern/6:00pm Central/5:00pm Mountain/4:00pm Pacific
Hosted by University of Toronto

Efficacy of Vaginal Estradiol or Vaginal Moisturizer vs Placebo for Treating Postmenopausal Vulvovaginal Symptoms

 

Wednesday, September 28, 2022
7:30pm Eastern/6:30pm Central/5:30pm Mountain/4:30pm Pacific
Hosted by University of Alberta

A Comparative Study on the Effects of High-Intensity Focused Electromagnetic Technology and Electrostimulation for the Treatment of Pelvic Floor Muscles and Urinary Incontinence in Parous Women: Analysis of Posttreatment Data 

Electromyographic Evaluation of the Pelvic Muscles Activity After High-Intensity Focused Electromagnetic Procedure and Electrical Stimulation in Women With Pelvic Floor Dysfunction 

Safety and Efficacy of a Non-Invasive High-Intensity Focused Electromagnetic Field (HIFEM) Device for Treatment of Urinary Incontinence and Enhancement of Quality of Life 

 

Fellowship Programs

Female Pelvic Medicine and Reconstructive Surgery (FPMRS) Fellowship Information Night 


Date:
April 17, 2024
Time: 8:30PM Newfoundland/8:00PM Antlantic/7:00PM Eastern/6:00PM Central/5:00PM Mountain/4:00PM Pacific
Zoom: https://us06web.zoom.us/j/85079921667?pwd=spTIxXAufshbNKXkawaRmp5XL2bJdI.1
Meeting ID: 850 7992 1667
Passcode: 492417

Attend this virtual meet & greet to gather information on:
• Key application details about each Canadian FPMRS Program
• Program features including unique features, salary, call requirements, locum opportunities, etc.
• Fellows attending from most Canadian programs available to answer questions

We look forward to meeting you!
CSPM Medical Education Committee
Fellow Representatives: Magdalene Payne, Jena Hall
Contact Details:
This email address is being protected from spambots. You need JavaScript enabled to view it.
This email address is being protected from spambots. You need JavaScript enabled to view it.


Dalhousie University
Program Director: Anita Smith, This email address is being protected from spambots. You need JavaScript enabled to view it.
Administrative Staff: Michelle Pineau, This email address is being protected from spambots. You need JavaScript enabled to view it.
Website: https://medicine.dal.ca/departments/department-sites/obstetrics/education/fellowships.html
Length of Program: 2 years
Accepting trainees every 2 years
Application Deadline: application deadline May 30 and decision date June 30 of the year before fellowship start
Documents Required: *see website (Postgrad application form; CV; letter of intent; 3 references; postgrad director letter)

McGill University
Program Director: Dr. Lisa Merovitz, This email address is being protected from spambots. You need JavaScript enabled to view it.
Admistrative Staff: Dolly Rabbath, Lisa Campbell, This email address is being protected from spambots. You need JavaScript enabled to view it.
Length of Program: 2 years
Accepting trainees every year
Application Deadline: May 15 and decision date June 30 of the year before fellowship start
Documents Required: Required documents are listed on the following website - https://www.mcgill.ca/pgme/fellowships/admissions,
CV, personal statement, 3 reference letters. A specialty Certificate if they have completed the program and a letter of standing from the Program Director.
Additional Note: Funding is available for a fellow for the years 2024-2026

McMaster University
Program Director: Dr. Ola Malabarey, 905-521-2100 ext. 76252
Administrative Staff: Heather Shiskoski, This email address is being protected from spambots. You need JavaScript enabled to view it.
Length of Program: 2 years
Accepting trainees every 2 years
Application Deadline: May 30 and decision date June 30 of the year before fellowship start
Documents Required: https://pgme.mcmaster.ca/apply/fellowships-application/

Schulich School of Medicine and Dentistry, Western University
Program Director: Dr. Queena Chou, This email address is being protected from spambots. You need JavaScript enabled to view it., Tel: (519) 646-6343
Administrative Staff: Samantha Kreamer, This email address is being protected from spambots. You need JavaScript enabled to view it. and Nicole Filson: This email address is being protected from spambots. You need JavaScript enabled to view it., Tel: (519) 685-8500 Ext 56362
Website: https://www.schulich.uwo.ca/obsgyn/education/fellowship_programs/urogynaecology.html
Length of program: 2 years
Accepting trainees every year
Application Deadline: May 30 and decision date June 30 of the year before fellowship start
Documents Required: Candidate Letter of Intent/Personal Statement, CV, 3 Letters of Reference
Additional Notes: Funding is available although individualized based on situation of the candidate (i.e., self-funded by sponsoring agency or not)

University of Alberta (Edmonton)

Program Director: Dr. Erin Kelly, This email address is being protected from spambots. You need JavaScript enabled to view it.
Administrative Staff: Tracey Curtis, This email address is being protected from spambots. You need JavaScript enabled to view it. 
Website: https://www.ualberta.ca/obstetrics-gynecology/education-programs/fellowship-and-postdoc-opportunities/female-pelvic-medicine-fellowship/index.html
Length of program: 2 years
Accepting trainees every 2 years
Application Deadline: May 30 and decision date June 30 of the year before fellowship start
Documents required for application: Application Process
Additional notes for applicants: Overview and Funding and Financial Support

University of British Columbia
Program Director: Roxana Geoffrion, This email address is being protected from spambots. You need JavaScript enabled to view it.
Administrative Staff: Mamta Rohra, This email address is being protected from spambots. You need JavaScript enabled to view it. 
Website: https://obgyn.ubc.ca/education/advanced-training-programs/fpmrs/
Length of Program: 2 years
Accepting 1 fellow every 2 years, next start for July 1, 2024
Application Deadline: May 30 and decision date June 30 of the year before fellowship start
Documents Required: Letter of intent, CV, 3 reference letters
Additional Notes: One-month electives in urogynecology at UBC are encouraged prior to application

University of Calgary
Program Director: Dr. Erin Brennand
Administrative Staff: Katiane Ummels, This email address is being protected from spambots. You need JavaScript enabled to view it.
Accepting fellows every 1 year, with some flexibility available for start dates between July and December
Application Deadline: May 30 and decision date June 30 of the year before fellowship start
Documents Required: CV, 3 Letters of Reference, Letter of Application explaining interest in Urogyne program

Université de Montréal
Program Director: Dr. Barbara Reichetzer, This email address is being protected from spambots. You need JavaScript enabled to view it. 
Administrative Staff: Sandra Charland, This email address is being protected from spambots. You need JavaScript enabled to view it., 514 890-8000, poste 32593
Website: https://deptobsgyn.umontreal.ca/etudes/stages-de-perfectionnement/urogynecologie-et-chirurgie-de-reconstruction-du-plancher-pelvien/
Length of Program: 2 years
Accepting trainees every 2 years
Application Deadline: May 30 and decision date June 30 of the year before fellowship start
Documents Require: Recommendation Letter, Motivation Letter, Resume

University of Ottawa / The Ottawa Hospital
Program Director: Hisham Khalil, BSc, MD, FRCSC, This email address is being protected from spambots. You need JavaScript enabled to view it.
Administrative Staff: Erica Moore, This email address is being protected from spambots. You need JavaScript enabled to view it.
Length of Program: 2 years
Accepting trainees every year
Application Deadline: May 30 and decision date June 30 of the year before fellowship start
Documents Required: 3 reference letters, letter of intent, CV

University of Toronto Urogynecology fellowship
Mount Sinai Hospital Urogynecology fellowship
Sunnybrook Urogynecology fellowship
Program Directors: Patricia Lee, This email address is being protected from spambots. You need JavaScript enabled to view it.; Danny Lovatsis, This email address is being protected from spambots. You need JavaScript enabled to view it.
Administrative Staff: Maureen, This email address is being protected from spambots. You need JavaScript enabled to view it.
Website: http://urogyne.ca/program-descriptions-application/#uoft
Length of program: 2 years
Accepting trainees: Typically, every year for the Joint Fellowship (variable for the Mt Sinai site only or Sunnybrook site only fellowships)
Application deadline: May 30 and decision date June 30 of the year before fellowship start
Documents required for application LOI, CV, 3 references and application form: https://obgyn.utoronto.ca/application-guidelines-and-document-checklist

 

Quebec Universities

Research Spotlight


Research Highlights

  • Dr. Maryse Larouche (Urogynecologist, McGill University), and Dr. Roxana Geoffrion (Urogynecologist, University of British Columbia) undertook a systematic review of apical prolapse surgical procedures. They published their systematic review and meta-analysis in Obstetrics &Gynecology (journal of the American College of Obstetricians and Gynecologists/ACOG).

    Sixty-two articles were included in the review. At 1 to 5 years after surgery, the authors reported that (1) There was more anatomic recurrence after sacrocolpopexy than vaginal suspensions; (2)  Minimally invasive sacrocolpopexy showed less overall anatomic recurrence than open sacrocolpopexy, but subjective outcomes were similar; (3) Hysterectomy and suspension vs. hysteropexy seemed to have similar outcomes in the short to medium term. Overall, outcome reporting of studies needs to be improved to allow meaningful comparisons of procedures. The Society of Obstetricians and Gynaecologists of Canada (SOGC) guideline No. 413 was developed based on this review and published in the JOGC.

    View publications:

    Systematic review: https://pubmed.ncbi.nlm.nih.gov/33957652/ 

    SOGC guideline: https://pubmed.ncbi.nlm.nih.gov/33548503/

  • Melanie Morin (Physiotherapist, PhD, University of Sherbrooke), Chantal Dumoulin (Physiotherapist, PhD, University of Montreal) and their colleagues published the results of a multicenter randomized controlled trial on treatment options for provoked vestibulodynia in the American Journal of Obstetrics and Gynecology. This research was funded by CIHR and FRQS . The authors recruited and randomized 212 women with provoked vestibulodynia and compared weekly multimodal physical therapy vs. overnight topical lidocaine (5% ointment) treatment (duration – 10 weeks). They found that physical therapy was more effective than lidocaine at reducing intensity of dyspareunia, and at improving sexual function. 195 (92%) patients completed 6-month follow-up. Overall, most women (79%) reported being very much or much improved after physical therapy vs. a minority (39%) of the lidocaine group (p<0.001).

    View publication: https://pubmed.ncbi.nlm.nih.gov/32818475/

 

2020-2021 Publication List

Larouche M, Belzile E, Geoffrion G. Surgical Management of Symptomatic Apical Pelvic Organ Prolapse: A Systematic Review and Meta-analysis. Obstet Gynecol 2021;137(6). doi: 10.1097/AOG.0000000000004393. [Epub ahead of print] PMID:

Geoffrion R, Larouche M. Guideline No. 413: Surgical Management of Apical Pelvic Organ Prolapse in Women. J Obstet Gynaecol Can. 2021 Apr;43(4):511-523.e1. doi: 10.1016/j.jogc.2021.02.001. Epub 2021 Feb 3. PMID: 33548503.

Roch M, Gaudreault N, Cyr MP, Venne G, Bureau NJ,Morin M. The Female Pelvic Floor Fascia Anatomy: A Systematic Search and Review. Life (Basel). 2021 Aug 30;11(9):900. doi: 10.3390/life11090900. PMID:34575049.

Thalmann M, Ringli L, Adcock M, Swinnen N, de Jong J, Dumoulin C, Guimarães V, de Bruin ED. Usability Study of a Multicomponent Exergame Training for Older Adults with Mobility Limitations. Int J Environ Res Public Health. 2021 Dec 20;18(24):13422. doi: 10.3390/ijerph182413422. PMID:34949028

Geoffrion R, Koenig NA, Zheng M, Sinclair N, Brotto L, Lee T, Larouche M. Preoperative depression and anxiety impact on inpatient surgery outcomes: A prospective cohort study. Ann Surg Open. 2021 Mar;2(1):e049. doi: 10.1097/AS9.0000000000000049.

Frawley H, Shelly B,Morin M, Bernard S, Bø K, Digesu GA, Dickinson T, Goonewardene S, McClurg D, Rahnama'i MS, Schizas A, Slieker-Ten Hove M, Takahashi S, Voelkl Guevara J. An International Continence Society (ICS) report on the terminology for pelvic floor muscle assessment. Neurourol Urodyn. 2021 Jun;40(5):1217-1260. doi: 10.1002/nau.24658. PMID:

Morin M,Dumoulin C, Bergeron S, Mayrand MH, Khalifé S, Waddell G, Dubois MF; PVD Study Group. Multimodal physical therapy versus topical lidocaine for provoked vestibulodynia: a multicenter, randomized trial. Am J Obstet Gynecol. 2021 Feb;224(2):189.e1-189.e12. doi: 10.1016/j.ajog.2020.08.038. PMID:32818475.

Capmas P, Larouche M, Suhartana E. Conversion rate of laparoscopic or robotic to open sacrocolpopexy: are there associated factors and complications? Int Urogynecol J. 2020 Oct 26. doi: 10.1007/s00192-020-04570-4.[Epub ahead of print] PMID: 33104825. 

Larouche MAlbert AYK, Lipsky N, Walmsley S, Loutfy M, Smaill F, Trottier S, Bitnun A, Yudin MH, Cundiff GW, Money DM. Urinary Symptoms and Quality of Life in Women Living With HIV: A Cross-Sectional Study. Int Urogynecol J.2021 Feb;32(2):353-358. doi: 10.1007/s00192-020-04343-z.Epub 2020 May 22. PMID: 32440885.

Le Berre M,Presse N,Morin MLarouche MCampeau LHu YXReid IDumoulin C. What do we really know about the role of caffeine on urinary tract symptoms? A scoping review on caffeine consumption and lower urinary tract symptoms in adults. Neurourol Urodyn. 2020 Jun;39(5):1217-1233. doi: 10.1002/nau.24344. Epub 2020 Apr 9. PMID: 32270903.

Bentaleb J, Larouche M. Innovative use of artificial intelligence in urogynecology. Int Urogynecol J. 2020 Jul;31(7):1287-1288.doi: 10.1007/s00192-020-04243-2. Epub 2020 Feb 13. PMID: 32055869.

Cacciari LP, Kruger J, Goodman J, Budgett D, Dumoulin C. Reliability and validity of intravaginal pressure measurements with a new intravaginal pressure device: The FemFit®. Neurourol Urodyn. 2020 Jan;39(1):253-260. doi: 10.1002/nau.24179. Epub 2019 Oct 6. PMID:31588623

Lisonkova S, Geoffrion R, Sanaee M, Muraca GM, Wen Q, Yong PJ, Larouche M, Cundiff GW. Regional variation and temporal trends in surgery for pelvic organ prolapse in Canada, 2004-2014. J Obstet Gynaecol Can. 2020 Jul;42(7):846-852.e5. doi: 10.1016/j.jogc.2019.12.016. Epub 2020 Mar 12. PMID: 32173237.

El-Sayegh B, Dumoulin C, Ali M, Assaf H, Sawan M. A Dynamometer-based Wireless Pelvic Floor Muscle Force Monitoring. Annu Int Conf IEEE Eng Med Biol Soc. 2020 Jul;2020:6127-6130. doi: 10.1109/EMBC44109.2020.9176660. PMID:33019369

Cacciari LP, Amorim AC, Pássaro AC, Dumoulin C, Sacco ICN. Intravaginal pressure profile of continent and incontinent women. J Biomech. 2020 Jan 23;99:109572. doi: 10.1016/j.jbiomech.2019.109572. PMID:31931973

Swinnen N, de Bruin ED, Dumoulin C, Thalmann M, Guimarães V, De Jong J, Vandenbulcke M, Vancampfort D. The VITAAL Stepping Exergame Prototype for Older Adults With Major Neurocognitive Disorder: A Usability Study. Front Aging Neurosci. 2021 Nov 4;13:701319. doi: 10.3389/fnagi.2021.701319. eCollection 2021. PMID:

Pedofsky L, Nielsen PMF, Budgett D, Nemec K, Dumoulin C, Kruger J. Using codesign to develop a mobile application for pelvic floor muscle training with an intravaginal device (femfit®). Neurourol Urodyn. 2021 Nov;40(8):1900-1907. doi: 10.1002/nau.24775. Epub 2021 Aug 31. PMID:

Padoa A, McLean L,Morin M, Vandyken C. The Overactive Pelvic Floor (OPF) and Sexual Dysfunction. Part 2: Evaluation and Treatment of Sexual Dysfunction in OPF Patients. Sex Med Rev. 2021 Jan;9(1):76-92. doi: 10.1016/j.sxmr.2020.04.002. PMID:32631813.

Padoa A, McLean L,Morin M, Vandyken C. "The Overactive Pelvic Floor (OPF) and Sexual Dysfunction" Part 1: Pathophysiology of OPF and Its Impact on the Sexual Response. Sex Med Rev. 2021 Jan;9(1):64-75. doi: 10.1016/j.sxmr.2020.02.002.PMID:32238325.

Paquin MH, Duclos C, Lapierre N, Dubreucq L, Morin M, Meunier J, Rousseau J, Dumoulin C. The effects of a strong desire to void on gait for incontinent and continent older community-dwelling women at risk of falls. Neurourol Urodyn. 2020 Feb;39(2):642-649. doi: 10.1002/nau.24234. Epub 2019 Nov 25. PMID:31765490

Dumoulin C, Morin M, Danieli C, Cacciari L, Mayrand MH, Tousignant M, Abrahamowicz M; Urinary Incontinence and Aging Study Group. Group-Based vs Individual Pelvic Floor Muscle Training to Treat Urinary Incontinence in Older Women: A Randomized Clinical Trial. JAMA Intern Med. 2020 Oct 1;180(10):1284-1293. doi: 10.1001/jamainternmed.2020.2993.PMID:32744599

Cyr MP,Dumoulin C, Bessette P, Pina A, Gotlieb WH, Lapointe-Milot K, Mayrand MH, Morin M. Feasibility, acceptability and effects of multimodal pelvic floor physical therapy for gynecological cancer survivors suffering from painful sexual intercourse: A multicenter prospective interventional study. Gynecol Oncol. 2020 Dec;159(3):778-784. doi: 10.1016/j.ygyno.2020.09.001. PMID:33010968 

Benoit-Piau J,Dumoulin C, Carroll MS, Mayrand MH, Bergeron S, Khalifé S, Waddell G, Morin M; Provoked Vestibulodynia (PVD) Study Group. Efficiency and Cost: E-Recruitment Is a Promising Method in Gynecological Trials. J Sex Med. 2020 Jul;17(7):1304-1311. doi: 10.1016/j.jsxm.2020.04.005. PMID:32434709

Dumoulin C, Cacciari L, Mayrand MH. Implementing Group-Based Pelvic Floor Muscle Training in Clinical Practice-Reply. JAMA Intern Med. 2021 Mar 1;181(3):406-407. doi: 10.1001/jamainternmed.2020.7110. PMID:33315042.

Cyr MP,Dumoulin C, Bessette P, Pina A, Gotlieb WH, Lapointe-Milot K, Mayrand MH, Morin M. Changes in pelvic floor morphometry and muscle function after multimodal physiotherapy for gynaecological cancer survivors suffering from dyspareunia: a prospective interventional study. 2022 Mar;114:54-62. doi: 10.1016/j.physio.2021.09.003. PMID:35093737.

Cyr MP,Dumoulin C, Bessette P, Pina A, Gotlieb WH, Lapointe-Milot K, Mayrand MH, Morin M. A Prospective Single-Arm Study Evaluating the Effects of a Multimodal Physical Therapy Intervention on Psychosexual Outcomes in Women With Dyspareunia After Gynecologic Cancer. J Sex Med. 2021 May;18(5):946-954. doi: 10.1016/j.jsxm.2021.02.014. PMID:33931347 

Cyr MP,Dumoulin C, Bessette P, Pina A, Gotlieb WH, Lapointe-Milot K, Morin M.Characterizing Pelvic Floor Muscle Function and Morphometry in Survivors of Gynecological Cancer Who Have Dyspareunia: A Comparative Cross-Sectional Study. Phys Ther. 2021 Apr 4;101(4):pzab042. doi: 10.1093/ptj/pzab042.PMID:

Cacciari LP, Morin M, Mayrand MH, Tousignant M, Abrahamowicz M,Dumoulin C. Pelvic floor morphometrical and functional changes immediately after pelvic floor muscle training and at 1-year follow-up, in older incontinent women. Neurourol Urodyn. 2021 Jan;40(1):245-255. doi: 10.1002/nau.24542. PMID:33075192

McGill University 

Research Spotlight


Publication Highlight

Covarrubias C, Cammisotto PG, Shamout S, Campeau L. Decrease in the ratio proBDNF/BDNF in the urine of aging female patients with OAB. Metabolites 2023 Jun 3;13(6):723.  PMID: 37367881. DOI: 10.3390/metabo13060723

An indisputable link exists between neurotrophins and growth factors (i.e., nerve growth factor/NGF, its precursor, proNGF), and overactive bladder syndrome (OAB). Thus, the team of Dr Lysanne Campeau, Associate Professor of Surgery at McGill University, first aimed to develop a non-invasive tool for diagnosing OAB syndrome in the urine of aging women. MicroRNAs related to NGF and proNGF metabolism (miR-491-5p and miR-592) that negatively control the translation of the matrix metalloproteinase-9 (MMP-9, the primary enzyme degrading NGF) were detected in void urine. Levels of miR-491-5p, the main miRNA that downregulates MMP-9 synthesis, were significantly decreased in urine from OAB patients. Next, concentrations of brain-derived neurotrophic factor (BDNF) and its precursor (proBDNF) were measured in the urine of a cohort of aging female patients with OAB. The ratio of proBDNF/BDNF was significantly decreased in the OAB group, while the level of MMP-9, the enzyme that cleaves proBDNF into BDNF, was increased in OAB compared to controls. These results suggest that neurotrophins are regulated at the levels of proteolytic enzymes converting pro-form to mature form rather than the translational levels; the ratio proBDNF/BDNF could be useful in the phenotyping of OAB in an aging population, and the difference could originate from enhanced MMP-9 enzymatic activity. Their studies confirm the diagnostic and phenotyping value of the urinary ratio proBDNF over mature BDNF. 

2022-2023 Publication List

Kakkar A, Reuveni-Salzman A, Bentaleb J, Belzile E, Merovitz L, Larouche M. Adverse events associated with pessary use over one year among women attending a pessary care clinic. Int Urogynecol J. 2023. Aug;34(8):1765-1770. PMID: 36715742. IF 1.932 doi: 10.1007/s00192-023-05462-z. 

Raina J, Bastrash M-P, Suarthana E, Larouche M. Perioperative complication rates of colpocleisis performed with or without hysterectomy a large population-based study. Int Urogynecol J. 2023. May;34(5):1111-1118. PMID: 36705729. (IF 1.932).  doi: 10.1007/s00192-023-05457-w

Busque AA, Belzile E, Rodrigues K, Larouche M. Major perioperative complications of benign gynecologic procedures at a university-affiliated hospital. McGill Journal of Medicine 2022, 21(6):1-12.

Nguyen LN, Randhawa H, Nadeau G, Cox A, Hickling D, Campeau L, Li J, Welk B, Carlson K. Canadian Urological Association best practice report: diagnosis and management of nocturia. Canadian Urological Association Journal. 2022 Jul;16(7): E336-349. PMID: 35819914. DOI: 10.5489/cuaj.7970

Cammisotto PG, Mossa AH, Shamout S, Campeau L. Urinary levels of miR-491-5p and miR-592 as potential diagnostic biomarkers in female aging patients with OAB: a pilot study. Metabolites 2022 Aug 31;12(9):820. PMID: 36144224. DOI: 10.3390/metabo12090820

Covarrubias C, Cammisotto PG, Shamout S, Campeau L. Decrease in the ratio proBDNF/BDNF in the urine of aging female patients with OAB. Metabolites 2023 Jun 3;13(6):723.  PMID: 37367881.

DOI: 10.3390/metabo13060723

Bouchard, B., Campeau, L. Quality, Value, and Efficacy of Complementary and Alternative Medicine in the Treatment of Interstitial Cystitis/Bladder Pain Syndrome. Curr Bladder Dysfunct Rep 18, 51–58 (2023).

McGill University 

Research Spotlight


Publication Highlight

Covarrubias C, Cammisotto PG, Shamout S, Campeau L. Decrease in the ratio proBDNF/BDNF in the urine of aging female patients with OAB. Metabolites 2023 Jun 3;13(6):723.  PMID: 37367881. DOI: 10.3390/metabo13060723

An indisputable link exists between neurotrophins and growth factors (i.e., nerve growth factor/NGF, its precursor, proNGF), and overactive bladder syndrome (OAB). Thus, the team of Dr Lysanne Campeau, Associate Professor of Surgery at McGill University, first aimed to develop a non-invasive tool for diagnosing OAB syndrome in the urine of aging women. MicroRNAs related to NGF and proNGF metabolism (miR-491-5p and miR-592) that negatively control the translation of the matrix metalloproteinase-9 (MMP-9, the primary enzyme degrading NGF) were detected in void urine. Levels of miR-491-5p, the main miRNA that downregulates MMP-9 synthesis, were significantly decreased in urine from OAB patients. Next, concentrations of brain-derived neurotrophic factor (BDNF) and its precursor (proBDNF) were measured in the urine of a cohort of aging female patients with OAB. The ratio of proBDNF/BDNF was significantly decreased in the OAB group, while the level of MMP-9, the enzyme that cleaves proBDNF into BDNF, was increased in OAB compared to controls. These results suggest that neurotrophins are regulated at the levels of proteolytic enzymes converting pro-form to mature form rather than the translational levels; the ratio proBDNF/BDNF could be useful in the phenotyping of OAB in an aging population, and the difference could originate from enhanced MMP-9 enzymatic activity. Their studies confirm the diagnostic and phenotyping value of the urinary ratio proBDNF over mature BDNF. 

2022-2023 Publication List

Kakkar A, Reuveni-Salzman A, Bentaleb J, Belzile E, Merovitz L, Larouche M. Adverse events associated with pessary use over one year among women attending a pessary care clinic. Int Urogynecol J. 2023. Aug;34(8):1765-1770. PMID: 36715742. IF 1.932 doi: 10.1007/s00192-023-05462-z. 

Raina J, Bastrash M-P, Suarthana E, Larouche M. Perioperative complication rates of colpocleisis performed with or without hysterectomy a large population-based study. Int Urogynecol J. 2023. May;34(5):1111-1118. PMID: 36705729. (IF 1.932).  doi: 10.1007/s00192-023-05457-w

Busque AA, Belzile E, Rodrigues K, Larouche M. Major perioperative complications of benign gynecologic procedures at a university-affiliated hospital. McGill Journal of Medicine 2022, 21(6):1-12.

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